期刊
ORGANIC LETTERS
卷 23, 期 7, 页码 2498-2504出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00446
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资金
- Royal Society [URF/R/191015]
- AstraZeneca
- EPSRC
The use of stoichiometric organoborane reductants in organic synthesis has been well established. In this study, these reagents were rendered catalytic through an isodesmic B-O/B-H transborylation, enabling borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The proposed mechanism of catalysis involves 1,4-hydroboration and B-O/B-H transborylation as key steps, supported by single-turnover and isotopic labeling experiments.
The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.
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