Oxepin Formation in Fungi Implies Specific and Stereoselective Ring Expansion

Oxepinamides are fungal oxepine-pyrimidinone-ketopiperazine derivatives. In this study, we elucidated the biosynthetic pathway of oxepinamide D in Aspergillus ustus by gene deletion, heterologous expression, feeding experiments, and enzyme assays. We demonstrated that the cytochrome P450 enzymes catalyzed highly specific and stereoselective oxepin ring formation.

Automated summary

In this study, the biosynthetic pathway of oxepinamide D in Aspergillus ustus was elucidated through gene deletion, heterologous expression, feeding experiments, and enzyme assays. It was demonstrated that cytochrome P450 enzymes catalyze highly specific and stereoselective oxepin ring formation.