Short and Modular Synthesis of Substituted 2-Aminopyrroles

We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-amino-pyrroles with diverse substituents have been prepared.

Automated summary

A simple and metal-free domino methodology was used to synthesize various 2-aminopyrroles from alkynyl vinyl hydrazides, involving a novel rearrangement and cyclization reaction. This approach allowed the preparation of 2-amino-pyrroles with diverse substituents.