期刊
OBESITY SURGERY
卷 31, 期 9, 页码 3990-3995出版社
SPRINGER
DOI: 10.1007/s11695-021-05442-6
关键词
Sleeve gastrectomy; Obesity; Vitamin D; Free Vitamin D
类别
资金
- IGTP-HUGTIP Biobank integrated in the Spanish National Biobanks Network of Instituto de Salud Carlos III [PT13/0010/0009]
- Tumour Bank Network of Catalonia
The study found that after sleeve gastrectomy, there was a significant increase in f25(OH)D3 concentrations in patients with morbid obesity, while 25(OH)D levels did not change significantly. One year post-surgery, patients with a BMI <35 kg/m(2) had significantly higher concentrations of f25(OH)D3 and 25(OH)D compared to those with a BMI >35 kg/m(2).
Background Total 25-OH-vitamin D (25(OH)D) levels are decreased in patients with obesity, but few data exist regarding free-vitamin D3 (f25(OH)D3) concentrations. We aimed to evaluate the effect of bariatric surgery on 25(OH)D and f25(OH)D3 in a cohort of patients with morbid obesity. Methods Twenty-four patients submitted to sleeve gastrectomy (SG) (mean age 48 years, body mass index (BMI) 48.16 +/- 10.73k/m(2)) were evaluated before and 1 year after surgery. Anthropometric data, parathormone (PTH), calcium, alkaline phosphatase, 25(OH)D, and f25(OH)D3 were recorded. Results 25(OH)D and f25(OH)D3 correlated well before and after SG. Baseline determinations did not correlate with BMI, but they inversely correlated with BMI 1 year after surgery (r(s)=-0.46, p=0.02 and r(s)=-0.60, p=0.002, respectively). Post-surgery % total body weight loss (%TBWL) was 27.4 +/- 13.8 %; f25(OH)D3 concentrations increased significantly (5.28 +/- 2.29 pg/mL vs 6.64 +/- 2.25 pg/mL; p=0.03), whereas 25(OH)D did not change. Patients who achieved a BMI <35 kg/m(2) 1 year after surgery had significantly higher concentrations of f25(OH)D3 (7.9 +/- 1 pg/mL vs 4.8 +/- 1.1, p<0.001) and 25(OH)D (30.9 +/- 9.4 ng/mL vs 22.3 +/- 13.4; p=0.03) compared to those who remained with BMI >35 kg/m(2). Conclusion There is a significant inverse relationship between BMI and both f25(OH)D3 and 25(OH)D 1 year after surgery. Only f25(OH)D3 concentrations increased 1 year after surgery, which could be explained by a greater f25(OH)D3 sequestration before SG in the adipose tissue, potentially due to the more liposoluble nature of f25(OH)D3 than the protein-bound form 25(OH)D.
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