期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 31, 期 7, 页码 2099-2108出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2021.03.021
关键词
Type 1 diabetes; Atherosclerosis; Cardiovascular risk; Glycoproteins; NMR-Glycoproteins; Carotid ultrasonography
资金
- Associacio Catalana de Diabetis (ACD)
In patients with type 1 diabetes, H-1-NMR glycoproteins were independently associated with the presence and extent of carotid atherosclerosis in those not receiving lipid-lowering treatment, unlike other classical inflammatory markers. Further research is needed to explore their potential as cardiovascular disease biomarkers.
Background and aims: Glycoproteins play a key role in inflammatory and cardiometabolic processes. Their implication in atherosclerosis in type 1 diabetes (T1D) is unknown. We assessed the relationships between classic inflammatory markers, glycoproteins measured by nuclear magnetic resonance (H-1-NMR), and preclinical atherosclerosis in these patients. Methods and results: We selected patients with T1D, without cardiovascular disease (CVD), with: age >= 40 years, nephropathy (micro/macroalbuminuria), or >= 10 years of evolution with another risk factor. The presence of plaque (intima-media thickness >1.5 mm) was determined by ultrasonography. Concentrations of high-sensitive C-reactive protein (hsCRP), circulating leukocytes (classical inflammation markers) and H-1-NMR-glycoproteins (GlycA, GlycB, GlycF, and the height/width [H/W] ratios of GlycA and GlycB) were determined. We included 189 patients (58% male, age 47.0 [40.7-55.2] years). Thirty-five percent presented plaques (22%, >= 2 plaques). There was no association between hsCRP or leukocytes and atherosclerosis. However, in age- and sex-adjusted models, GlycA, GlycF, and the H/W ratios of GlycA and GlycB gradually increased with the number of plaques (0, 1, >= 2 plaques) only in patients without statins (p < 0.05), with no association in patients receiving this drug (p for interaction <0.05; in >= 2 plaques). Finally, in models adjusted for other classical and T1D-specific risk factors, GlycA and GlycB H/W ratios remained associated with carotid plaque (OR 1.39 [1.12-1.90] and OR 6.89 [1.85-25.62], respectively). Conclusion: InT1D individuals without lipid-lowering treatment,H-1-NMR-glycoproteins were independently associated with the presence and amount of carotid atherosclerosis, unlike other classical inflammatory markers. Further studies are needed to ascertain their utility as CVD biomarkers. (C) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
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