期刊
NEW PHYTOLOGIST
卷 231, 期 3, 页码 963-973出版社
WILEY
DOI: 10.1111/nph.17428
关键词
adaptor proteins; Arabidopsis thaliana; corepressor; EAR motif; gene expression; hormone signalling; repression domain; TOPLESS (TPL)
资金
- BBSRC
- Leverhulme Trust
Transcriptional corepressors, particularly the TOPLESS (TPL) family, are crucial for regulating gene expression in plant growth and development. TPL proteins are essential for various developmental processes and responses to external challenges. Understanding the evolutionary history and mechanism of action of these plant-specific proteins can provide insights into their significance in plant development.
Transcriptional corepressors play important roles in establishing the appropriate levels of gene expression during growth and development. The TOPLESS (TPL) family of corepressors are critical for all plant life. TPLs are involved in numerous developmental processes and in the response to extrinsic challenges. As such these proteins have been the focus of intense study since Long and colleagues first described the TPL corepressor in 2006. In this review we will explore the evolutionary history of these essential plant-specific proteins, their mechanism of action based on recent structural analyses, and the myriad of pathways in which they function. We speculate how relatively minor changes in the peptide sequence of transcriptional regulators allowed them to recruit TPL into new processes, driving innovation and resulting in TPL becoming vital for plant development.
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