4.6 Article

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

Tangui Maurice

Summary: The sigma-1 receptor (S1R) is a conserved protein with high therapeutic potential for neurodegenerative diseases, especially with drugs like pridopidine. S1R agonists modulate inter-organelle communication, activate intracellular survival pathways, and exhibit a bi-phasic dose-response effect. More research is needed to fully understand the cellular nature of this chaperone protein for the development of promising molecules.

EXPERT OPINION ON DRUG DISCOVERY (2021)

Review Pharmacology & Pharmacy

Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain

James Michael Brimson et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

Article Neurosciences

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Chelsy R. Eddings et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Biochemistry & Molecular Biology

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

Alice Rossi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Multidisciplinary Sciences

Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy

Nathalie Bernard-Marissal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Dagmar E. Ehrnhoefer et al.

HUMAN MOLECULAR GENETICS (2018)

Article Neurosciences

MCU Interacts with Mirol to Modulate Mitochondrial Functions In Neurons

Robert F. Niescier et al.

JOURNAL OF NEUROSCIENCE (2018)

Article Pharmacology & Pharmacy

Regulation of ER-mitochondria contacts by Parkin via Mfn2

Valentina Basso et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Multidisciplinary Sciences

Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

Kyu-Sun Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biology

Isolation and Maintenance of Murine Embryonic Striatal Neurons

Luana Naia et al.

BIO-PROTOCOL (2018)

Review Cell Biology

Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases

Hibiki Kawamata et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Cell Biology

Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense

Tzu-Yu Weng et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity

Zhong-Xiao Fu et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice

Marta Garcia-Miralles et al.

JCI INSIGHT (2017)

Article Biochemistry & Molecular Biology

Mitochondrial Ca2+ handling in Huntington's and Alzheimer's diseases - Role of ER-mitochondria crosstalk

Luana Naia et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

Seiji Watanabe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Pridopidine activates neuroprotective pathways impaired in Huntington Disease

Michal Geva et al.

HUMAN MOLECULAR GENETICS (2016)

Review Neurosciences

There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases

Sebastien Paillusson et al.

TRENDS IN NEUROSCIENCES (2016)

Review Pharmacology & Pharmacy

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

Tsung-Ping Su et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Multidisciplinary Sciences

Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment

Isabel Onofre et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Oxidative metabolism in YAC128 mouse model of Huntington's disease

James Hamilton et al.

HUMAN MOLECULAR GENETICS (2015)

Article Biochemical Research Methods

Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells

Bryan C. Dickinson et al.

NATURE PROTOCOLS (2013)

Article Multidisciplinary Sciences

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

Louise Hedskog et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell & Tissue Engineering

Human Pluripotent Stem Cell Differentiation into Authentic Striatal Projection Neurons

Alessia Delli Carri et al.

STEM CELL REVIEWS AND REPORTS (2013)

Article Biochemistry & Molecular Biology

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Estela Area-Gomez et al.

EMBO JOURNAL (2012)

Article Pharmacology & Pharmacy

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

Arindam Pal et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

Article Biotechnology & Applied Microbiology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Stuart M. Chambers et al.

NATURE BIOTECHNOLOGY (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

Low density of sigma1 receptors in early Alzheimer's disease

Masahiro Mishina et al.

ANNALS OF NUCLEAR MEDICINE (2008)

Article Biochemistry & Molecular Biology

Disease-specific induced pluripotent stem cells

In-Hyun Park et al.

Article Biochemistry & Molecular Biology

siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro

K Omi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

EJ Slow et al.

HUMAN MOLECULAR GENETICS (2003)