4.4 Review

Brain transcriptomics of nonhuman primates: A review

期刊

NEUROSCIENCE LETTERS
卷 753, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.135872

关键词

Transcriptomics; RNA sequencing; Brain; Nonhuman primate

资金

  1. National Key R&D Program of China [2018YFC1002104, 2016YFC1000601]
  2. National Natural Science Funds [81971381, 81771580]
  3. Outstanding Overseas Returnees Fund of the Peking University Third Hospital [BYSYLXHG2019002]

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This review summarizes the applications of transcriptomics in nonhuman primate brain studies, including investigations of brain development, aging, toxic effects and diseases. Transcriptomics, as a powerful tool with developmental potential, has been widely utilized in neuroscience.
The brain is one of the most important and intricate organs in our bodies. Interpreting brain function and illustrating the changes and molecular mechanisms during physiological or pathological processes are essential but sometimes difficult to achieve. In addition to histology, ethology and pharmacology, the development of transcriptomics alleviates this condition by enabling high-throughput observation of the brain at various levels of anatomical specificity. Moreover, because human brain samples are scarce, the brains of nonhuman primates are important alternative models. Here in this review, we summarize the applications of transcriptomics in nonhuman primate brain studies, including investigations of brain development, aging, toxic effects and diseases. Overall, as a powerful tool with developmental potential, transcriptomics has been widely utilized in neuroscience.

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