期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 127, 期 -, 页码 555-571出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.05.001
关键词
Mitochondria; Electron transport chain complex proteins; Antidepressive agents; Drugs; In vivo studies
资金
- Mitochondrial Innovation Initiative, MITO2i
- National Institute of Health Research Great Ormond Street Hospital Biomedical Research Centre
Medications used to treat neuropsychiatric disorders can have either positive or mixed effects on mitochondrial function, with only a few showing exclusively adverse effects. The preclinical studies discussed in this review may inform medication prescribing practices for individuals with psychopathology and impaired mitochondrial function.
Individuals with mitochondrial disease often present with psychopathological comorbidity, and mitochondrial dysfunction has been proposed as the underlying pathobiology in various psychiatric disorders. Several studies have suggested that medications used to treat neuropsychiatric disorders could directly influence mitochondrial function. This review provides a comprehensive overview of the effect of these medications on mitochondrial function. We collected preclinical information on six major groups of antidepressants and other neuropsychiatric medications and found that the majority of these medications either positively influenced mitochondrial function or showed mixed effects. Only amitriptyline, escitalopram, and haloperidol were identified as having exclusively adverse effects on mitochondrial function. In the absence of formal clinical trials, and until such trials are completed, the data from preclinical studies reported and discussed here could inform medication prescribing practices for individuals with psychopathology and impaired mitochondrial function in the underlying pathology.
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