Many roles for oligodendrocyte precursor cells in physiology and pathology

Oligodendrocyte precursor cells (OPCs) are a fourth resident glial cell population in the mammalian central nervous system. They are evenly distributed throughout the gray and white matter and continue to proliferate and generate new oligodendrocytes (OLs) throughout life. They were understudied until a few decades ago when immunolabeling for NG2 and platelet-derived growth factor receptor alpha revealed cells that are distinct from mature OLs, astrocytes, neurons, and microglia. In this review, we provide a summary of the known properties of OPCs with some historical background, followed by highlights from recent studies that suggest new roles for OPCs in certain pathological conditions.

Automated summary

Oligodendrocyte precursor cells are a unique cell population in the central nervous system, capable of generating new oligodendrocytes throughout life. Recent studies suggest potential new roles for these cells in certain pathological conditions.