期刊
NEURON
卷 109, 期 12, 页码 2009-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2021.04.014
关键词
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资金
- CAS-NWO International Cooperation Project of the Chinese Academy of Sciences [153D31KYSB20160081]
- NSFC-ISF International Collaboration Research Project [31861143034]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB32010000, XDA27010000]
- Key Research Program of Frontier Sciences, Chinese Academy of Sciences [QYZDBSSWSMC045]
- National Key R&D Program of China [2017YFA0103900, 2017YFA0103901]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- Youth Thousand Talents Plan
This study investigates the cortical circuit mechanism underlying flexible decision-making based on structural knowledge, showing that auditory cortex (ACx) neurons encode hidden task rule variable and require feedback input from the orbitofrontal cortex (OFC), which supports the knowledge-based updating mechanism.
Making flexible decisions based on prior knowledge about causal environmental structures is a hallmark of goal-directed cognition in mammalian brains. Although several association brain regions, including the orbitofrontal cortex (OFC), have been implicated, the precise neuronal circuit mechanisms underlying knowledge based decision-making remain elusive. Here, we established an inference-based auditory categorization task where mice performed within-session flexible stimulus re-categorization by inferring the changing task rules. We constructed a reinforcement learning model to recapitulate the inference-based flexible behavior and quantify the hidden variables associated with task structural knowledge. Combining two-photon population imaging and projection-specific optogenetics, we found that auditory cortex (ACx) neurons encoded the hidden task rule variable, which requires feedback input from the OFC. Silencing OFC-ACx input specifically disrupted re-categorization behavior. Direct imaging from OFC axons in the ACx revealed task state-related feedback signals, supporting the knowledge-based updating mechanism. Our data reveal a cortical circuit mechanism underlying structural knowledge-based flexible decision-making.
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