The mouse prefrontal cortex: Unity in diversity

The prefrontal cortex (PFC) is considered to constitute the highest stage of neural integration and to be devoted to representation and production of actions. Studies in primates have laid the foundation for theories regarding the principles of prefrontal function and provided mechanistic insights. The recent surge of studies of the PFC in mice holds promise for evolvement of present theories and development of novel concepts, particularly regarding principles shared across mammals. Here we review recent empirical work on the mouse PFC capitalizing on the experimental toolbox currently privileged to studies in this species. We conclude that this line of research has revealed cellular and structural distinctions of the PFC and neuronal activity with direct relevance to theories regarding the functions of the PFC. We foresee that data-rich mouse studies will be key to shed light on the general prefrontal architecture and mechanisms underlying cognitive aspects of organized actions.

Automated summary

Recent studies on the mouse PFC have utilized the experimental toolbox available for this species, revealing cellular and structural differences in the PFC and neuronal activity related to theories about PFC functions. These data-rich studies in mice are expected to provide insights into the general prefrontal architecture and mechanisms underlying cognitive aspects of organized actions.