期刊
NEUROLOGICAL SCIENCES
卷 42, 期 8, 页码 3479-3483出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-021-05301-3
关键词
Central pontine myelinolysis; Hyponatremia; Pathology; History
Central pontine myelinolysis (CPM) is a neurological disorder caused by rapid correction of serum sodium levels in patients with chronic hyponatremia. It is recommended to increase plasma sodium concentration by no more than 8 to 10 mmol/L per 24 h in patients with chronic hyponatremia.
Objectives Central pontine myelinolysis (CPM) is a neurological disorder characterized by damage to the myelin and oligodendrocytes in the pons. This review focuses on the history of CPM and the discovery of its association with the treatment of hyponatremia. Methods The author reviewed original publications regarding CPM, hyponatremia, and the treatment of hyponatremia. The author interviewed Dr. Robert Laureno who was a pioneer in CPM research with his animal work in dogs. Results Animal models demonstrated the role of the rapid correction of hyponatremia as causative of pontine and extrapontine myelinolytic lesions. Nevertheless, the importance of the speed of correction was widely denied. There were years of debates and only slow changes in expert guidelines. Conclusion CPM occurs as a consequence of a rapid rise in serum sodium in individuals with chronic hyponatremia. It is recommended to increase plasma sodium concentration by no more than 8 to 10 mmol/L per 24 h in chronic hyponatremia.
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