期刊
NEUROINFORMATICS
卷 20, 期 2, 页码 285-299出版社
HUMANA PRESS INC
DOI: 10.1007/s12021-021-09518-7
关键词
Functional brain connectivity; Complex networks; Link difference ranking; Alzheimer’ s disease; Schizophrenia
资金
- European Research Council (ERC) under the European Union [851255]
- Horizon 2020 Framework Programme of the European Union
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health ) [U01 AG024904]
- DOD ADNI (Department of Defense award) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd.
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- European Research Council (ERC) [851255] Funding Source: European Research Council (ERC)
Quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance are highly non-trivial tasks. Link ranking differences induce specific geometries in a convenient auxiliary space, providing fast and reliable criteria for network reconstruction parameters.
Anatomical and dynamical connectivity are essential to healthy brain function. However, quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance are highly non-trivial tasks. Here we show that link ranking differences induce specific geometries in a convenient auxiliary space that are often easily recognisable at mere eye inspection. Link ranking can also provide fast and reliable criteria for network reconstruction parameters for which no theoretical guideline has been proposed.
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