期刊
NEUROIMAGE
卷 229, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.117698
关键词
Transcranial magnetic stimulation; Structural connectivity; Network; Default mode network; Dorsal attention network
资金
- MIT-Harvard Broad institute [6600024-5500000895]
- Beth Israel Deaconess Medical Center (BIDMC) via the Chief Academic Officer (CAO)
- Defense Advanced Research Projects Agency (DARPA) [HR001117S0030]
- NIH [P01 AG031720-06A1, R01 MH117063-01, R01 AG06098101, R01 MH115949, R01AG060987]
- National Institutes of Health [R01HD069776, R01NS073601, R21 MH099196, R21 NS082870, R21 NS085491, R21 HD07616]
This study found that in TMS-evoked activity, the modularity and structural integrity of the stimulated network are more important than targeted regions or whole-brain connectivity, and the importance of network structural connectivity was only revealed by TMS-evoked activity, not resting-state data. Future clinical interventions may benefit from adopting DWI-guided, network-focused TMS to enhance target engagement.
Information processing in the brain is mediated by structural white matter pathways and is highly dependent on topological brain properties. Here we combined transcranial magnetic stimulation (TMS) with high-density electroencephalography (EEG) and Diffusion Weighted Imaging (DWI), specifically looking at macroscale connectivity to understand whether regional, network-level or whole-brain structural properties are more responsible for stimulus propagation. Neuronavigated TMS pulses were delivered over two individually defined nodes of the default mode (DMN) and dorsal attention (DAN) networks in a group of healthy subjects, with test-retest reliability assessed 1-month apart. TMS-evoked activity was predicted by the modularity and structural integrity of the stimulated network rather than the targeted region(s) or the whole-brain connectivity, suggesting network-level structural connectivity as more relevant than local and global brain properties in shaping TMS signal propagation. The importance of network structural connectome was unveiled only by evoked activity, but not resting-state data. Future clinicals interventions might enhance target engagement by adopting DWI-guided, network-focused TMS.
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