期刊
NEUROIMAGE
卷 231, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2021.117862
关键词
Functional MRI; Neural activity; Neurovascular coupling; Microstructure
资金
- European Research Council (ERC) [679058]
- Fundacao para a Ciencia e Tecnologia (Portugal) [LISBOA-01-0145-FEDER-022170, 275-FCT-PTDC/BBB-IMG/5132/2014]
- Lisboa Regional Operational Programme (Lisboa 2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF)
A study has found a direct link between the rapid onset dfMRI signal and IOSs, demonstrating a punctate quantitative correspondence between the two; this signal component is rather insensitive to a vascular challenge. This suggests that neuromorphological coupling can be detected via dfMRI signals.
Functional Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function in-vivo. However, the neurovascular coupling mechanisms underlying fMRI are somewhat distant from neural activity. Interestingly, evidence from Intrinsic Optical Signals (IOSs) indicates that neural activity is also coupled to (sub)cellular morphological modulations. Diffusion-weighted functional MRI (dfMRI) experiments have been previously proposed to probe such neuromorphological couplings , but the underlying mechanisms have remained highly contested. Here, we provide the first direct link between in vivo ultrafast dfMRI signals upon rat forepaw stimulation and IOSs in acute slices stimulated optogenetically. We reveal a hitherto unreported rapid onset ( < 100 ms) dfMRI signal component which (i) agrees with fast-rising IOSs dynamics; (ii) evidences a punctate quantitative correspondence to the stimulation period; and (iii) is rather insensitive to a vascular challenge. Our findings suggest that neuromorphological coupling can be detected via dfMRI signals, auguring well for future mapping of neural activity more directly compared with blood-oxygenation-level-dependent mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据