期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 33, 期 12, 页码 -出版社
WILEY
DOI: 10.1111/nmo.14145
关键词
abdominal pain; irritable bowel syndrome; oral; patient preference; subcutaneous
资金
- Rose Pharma LLC
- Marc and Sheri Rapaport Fund for Digital Health Sciences & Precision Health
- CTSI grant from the NIH/NCATS [UL1TR001881-01]
The study found that the majority of patients with irritable bowel syndrome experience breakthrough pain, with efficacy being the most important factor in treatment decision-making. Most patients are willing to use rapid-acting subcutaneous treatments for acute pain relief.
Background Many patients with irritable bowel syndrome (IBS) experience acute and unexpected pain episodes over and above chronic background symptoms, and there are emerging medications designed to treat such pain. We aimed to use conjoint analysis-a technique that elucidates how people make complex decisions-to examine patient preferences for emerging medicines for breakthrough IBS pain. Methods We conducted a cross-sectional conjoint analysis survey among patients with Rome IV IBS and recurrent episodes of acute pain to assess the relative importance of medication attributes in their decision-making. We also assessed what respondents would require of subcutaneous (SQ) therapies to consider their use. Key Results Among 629 patients with Rome IV IBS, 606 (96.3%) reported >= 1 acute pain episodes in the past month. For the 461 participants with multiple attacks who completed the conjoint analysis, they prioritized medication efficacy (importance score 34.9%), avoidance of nausea (24.3%), and avoidance of constipation (12.2%) as most important in their decision-making. These were followed by route of administration (10.3%), avoidance of headache (9.3%), and avoidance of drowsiness (8.9%). Moreover, 431 (93.5%) participants would consider SQ therapies for their acute pain; they had varying expectations on the minimum pain decrease and onset and duration of pain relief needed for considering their use. Conclusions and Inferences The vast majority of patients with IBS experience breakthrough pain, and when selecting among therapies, they prioritize efficacy and most are willing to use a rapid-acting SQ treatment. These results support development of novel, effective medications-oral or SQ-for management of acute pain attacks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据