期刊
NEUROCHEMISTRY INTERNATIONAL
卷 145, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.104987
关键词
Microglia; Chronic stress; Neuroinflammation; Glucocorticoids; Neuropsychiatric disorders; Neurodegenerative diseases
资金
- Canadian Institutes of Health Research (CIHR) [353750]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-05308-2014]
- Fonds de recherche du Quebec -Sante (FRQS) doctoral awards
- Canadian Institutes of Health Research (CIHR)
- FRQS doctoral award
- CIHR
- Michael Smith Foundation for Health Research (MSFHR)
Microglia are resident macrophages of the central nervous system that can adjust their functions according to physiological needs. Chronic stress may alter the functions of microglia, leading to their involvement in neurological disorders.
Microglia, the resident macrophage cells of the central nervous system (CNS), are involved in a myriad of processes required to maintain CNS homeostasis. These cells are dynamic and can adapt their phenotype and functions to the physiological needs of the organism. Microglia rapidly respond to changes occurring in their microenvironment, such as the ones taking place during stress. While stress can be beneficial for the organism to adapt to a situation, it can become highly detrimental when it turns chronic. Microglial response to prolonged stress may lead to an alteration of their beneficial physiological functions, becoming either maladaptive or proinflammatory. In this review, we aim to summarize the effects of chronic stress exerted on microglia through the neuroendocrine system and inflammation at adulthood. We also discuss how these effects of chronic stress could contribute to microglial involvement in neuropsychiatric and sleep disorders, as well as neurodegenerative diseases.
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