期刊
NEUROCHEMICAL RESEARCH
卷 46, 期 8, 页码 1941-1952出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-021-03314-0
关键词
Sleep deprivation; Cognitive impairment; Hydrogen sulfide; Autophagy; Silent information regulator 1
资金
- National Natural Science Foundation of China [81771178]
- Natural Science Foundation of Hunan province [2019JJ80101]
- Major Research Topics of the Health Commission of Hunan province [20201911]
The study showed that H2S can reverse cognitive impairment caused by SD and inhibit excessive hippocampal autophagy induced by SD in rats, possibly through upregulation of Sirt-1.
Sleep deprivation (SD) is widespread in society causing serious damage to cognitive function. Hydrogen sulfide (H2S), the third gas signal molecule, plays important regulatory role in learning and memory functions. Inhibition of excessive autophagy and upregulation of silent information regulator 1 (Sirt-1) have been reported to prevent cognitive dysfunction. Therefore, this present work was to address whether H2S attenuates the cognitive impairment induced by SD in Wistar rats and whether the underlying mechanisms involve in inhibition of excessive autophagy and upregulation of Sirt-1. After treatment with SD for 72 h, the cognitive function of Wistar rats was evaluated by Y-maze, new object recognition, object location, and Morris water maze tests. The results shown that SD-caused cognitive impairment was reversed by treatment with NaHS (a donor of H2S). NaHS also prevented SD-induced hippocampal excessive autophagy, as evidenced by the decrease in autophagosomes, the down-regulation of Beclin1, and the up-regulation of p62 in the hippocampus of SD-exposed Wistar rats. Furthermore, Sirtinol, an inhibitor of Sirt-1, reversed the inhibitory roles of NaHS in SD-induced cognitive impairment and excessive hippocampal autophagy in Wistar rats. Taken together, our results suggested that H2S improves the cognitive function of SD-exposed rats by inhibiting excessive hippocampal autophagy in a hippocampal Sirt-1-dependent way.
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