4.7 Article

The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury

Ha Neui Kim et al.

Summary: The study demonstrates that genetic blockade of PAR1 in female mice results in improvements in sensorimotor co-ordination after thoracic spinal cord lateral compression injury. These improvements are accompanied by enhanced neuron preservation, myelin resiliency and repair, as well as reduced pro-inflammatory markers in astrocytes and microglia/monocytes. The loss of PAR1 function in astrocytes promotes both neuron survival and neurite outgrowth, highlighting its role in regulating glial-neuron interactions and neurotrophic factor signaling for CNS injury response and regenerative repair.
Article Neurosciences

Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain

Hyesook Yoon et al.

JOURNAL OF NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Injured adult neurons regress to an embryonic transcriptional growth state

Gunnar H. D. Poplawski et al.

NATURE (2020)

Article Multidisciplinary Sciences

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

Noriko Itoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Cell & Tissue Engineering

Microenvironment Imbalance of Spinal Cord Injury

Baoyou Fan et al.

CELL TRANSPLANTATION (2018)

Article Multidisciplinary Sciences

Required growth facilitators propel axon regeneration across complete spinal cord injury

Mark A. Anderson et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

BDNF, Brain, and Regeneration: Insights from Zebrafish

Carla Lucini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Heather A. Ferris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Critical Care Medicine

Minimal Traumatic Brain Injury in Mice: Protease-Activated Receptor 1 and Thrombin-Related Changes

Zeev Itsekson-Hayosh et al.

JOURNAL OF NEUROTRAUMA (2016)

Article Neurosciences

Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair

Kavitha Abiraman et al.

JOURNAL OF NEUROSCIENCE (2015)

Review Cell Biology

PTEN inhibition and axon regeneration and neural repair

Yosuke Ohtake et al.

NEURAL REGENERATION RESEARCH (2015)

Review Cell Biology

Cholesterol metabolism and homeostasis in the brain

Juan Zhang et al.

PROTEIN & CELL (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing

Krishna R. Kalari et al.

BMC BIOINFORMATICS (2014)

Article Geriatrics & Gerontology

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

Marie Orre et al.

NEUROBIOLOGY OF AGING (2014)

Review Neurosciences

BDNF signaling and survival of striatal neurons

Maryna Baydyuk et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases

Hyesook Yoon et al.

BIOLOGICAL CHEMISTRY (2013)

Article Pathology

Kallikrein Cascades in Traumatic Spinal Cord Injury: In Vitro Evidence for Roles in Axonopathy and Neuron Degeneration

Maja Radulovic et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Biochemical Research Methods

RSeQC: quality control of RNA-seq experiments

Liguo Wang et al.

BIOINFORMATICS (2012)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Developmental Biology

Brain-Derived Neurotrophic Factor and the Development of Structural Neuronal Connectivity

Susana Cohen-Cory et al.

DEVELOPMENTAL NEUROBIOLOGY (2010)

Article Neurosciences

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

Kimberly J. Christie et al.

JOURNAL OF NEUROSCIENCE (2010)

Review Neurosciences

Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function

Cecily E. Hamill et al.

EXPERIMENTAL NEUROLOGY (2009)

Article Biotechnology & Applied Microbiology

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead et al.

GENOME BIOLOGY (2009)

Article Critical Care Medicine

A graded forceps crush spinal cord injury model in mice

Jason R. Plemel et al.

JOURNAL OF NEUROTRAUMA (2008)

Article Multidisciplinary Sciences

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

Kevin Kyungsuk Park et al.

SCIENCE (2008)

Article Neurosciences

Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development

Shingo Suzuki et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Neurosciences

Dynamic role of kallikrein 6 in traumatic spinal cord injury

I. A. Scarisbrick et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

Article Neurosciences

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury

O Nicole et al.

JOURNAL OF NEUROSCIENCE (2005)

Review Cell Biology

Cholesterol homeostasis in neurons and glial cells

JE Vance et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2005)

Review Hematology

Brain cholesterol:: Long secret life behind a barrier

I Björkhem et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

CE Junge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Biochemistry & Molecular Biology

Role of cholesterol in synapse formation and function

FW Pfrieger

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)

Review Neurosciences

Proteinase-activated receptors in the nervous system

F Noorbakhsh et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Article Biochemistry & Molecular Biology

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

ZM Suo et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Multidisciplinary Sciences

CNS synaptogenesis promoted by glia-derived cholesterol

DH Mauch et al.

SCIENCE (2001)

Review Cell Biology

Statins: mechanism of action and effects

C Stancu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2001)