期刊
NEUROBIOLOGY OF AGING
卷 101, 期 -, 页码 224-229出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.01.026
关键词
Alzheimer’ s disease; Mild cognitive impairment; Metabolic brain-age; Fluorodeoxyglucose; Positron emission tomography; Sex difference
资金
- Alzheimer's Society of Canada [13-32]
- Canadian Institute for Health Research [117121]
- Fonds de recherche du Quebec - Sante/Pfizer Canada - Pfizer-FRQS Innovation Fund [25262]
- National Institutes of Health [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- European Commission [283562]
- National Institute On Aging of the National Institutes of Health [5R01AG03158119]
- Genentech, Inc.
- Fonds de recherche Quebec-Sante
- NSERC
- Canada Research Chairs Secretariat
- Universitede Sherbrooke Research Chair
- [P50 AG05681]
- [P01 AG03991]
- [R01 AG021910]
- [P50 MH071616]
- [U24 RR021382]
- [R01 MH56584]
Sex differences play a significant role in brain metabolism among cognitively healthy individuals and those affected by cognitive impairment up to and including Alzheimer's disease. While healthy males exhibit older metabolic brain age compared to females, this distinction disappears in individuals with mild cognitive impairment and probable AD, suggesting a faster decline in brain glucose metabolism in females with cognitive impairment.
Sex differences play a vital role in human brain structure and physiology. Previous reports have proposed evidence hinting at a metabolic advantage in female brains across adulthood. It remained to be determined whether this advantage would be maintained across the spectrum of cognitive impairment, up to and including dementia due to Alzheimer's disease (AD). Here, using a machine-learning algorithm, we explore sex differences in metabolic brain-age derived from fluorodeoxyglucose positron emission tomography imaging among cognitively healthy individuals and those affected by mild cognitive impairment and clinically probable AD. First, we report that cognitively healthy male participants showed a persistently older looking brains when compared to healthy female participants in term of metabolic brain age, confirming earlier reports. However, this distinction disappeared among MCI individuals and probable AD patients, and this loss could not be explained by an accompanying neurodegeneration. This would seem to indicate that females have a higher rate of decline in brain glucose metabolism when cognitively impaired to negate their prior advantage. (c) 2021 Elsevier Inc. All rights reserved.
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