4.5 Article

Overexpression of protein kinase Mζ in the hippocampal dentate gyrus rescues amyloid-β-induced synaptic dysfunction within entorhinal-hippocampal circuit

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Overexpression of protein kinase Mζ in the hippocampus mitigates Alzheimer's disease-related cognitive deficit in rats

Niloufar Amini et al.

Summary: The overexpression of hippocampal PKM zeta can restore memory dysfunction induced by amyloidopathy in the early phase of AD, partly through preserving GluA2-containing AMPA receptors in the hippocampus. This suggests that PKM zeta's signaling pathway could be a potential therapeutic target for combating memory deficits in AD.

BRAIN RESEARCH BULLETIN (2021)

Review Pharmacology & Pharmacy

Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease

Dalila Mango et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Neurosciences

PKM ζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory

Janine I. Rossato et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Chen Chen et al.

SCIENTIFIC REPORTS (2016)

Article Neurosciences

Temporal phases of long-term potentiation (LTP): myth or fact?

Abdul-Karim Abbas et al.

REVIEWS IN THE NEUROSCIENCES (2015)

Article Medicine, Research & Experimental

Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis

Zhifang Dong et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemistry & Molecular Biology

PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP

Si-Qiang Ren et al.

EMBO JOURNAL (2013)

Article Multidisciplinary Sciences

Prkcz null mice show normal learning and memory

Anna M. Lee et al.

NATURE (2013)

Article Multidisciplinary Sciences

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

Lenora J. Volk et al.

NATURE (2013)

Article Multidisciplinary Sciences

Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

Ming Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Neurosciences

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

Paola Virginia Migues et al.

NATURE NEUROSCIENCE (2010)

Article Neurosciences

Prion-like mechanisms in neurodegenerative diseases

Bess Frost et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Erasing Sensorimotor Memories via PKMζ Inhibition

Lee Michael von Kraus et al.

PLOS ONE (2010)

Review Neurosciences

Alzheimer's disease: synaptic dysfunction and Aβ

Ganesh M. Shankar et al.

MOLECULAR NEURODEGENERATION (2009)

Article Biochemistry & Molecular Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories

Peter Serrano et al.

PLOS BIOLOGY (2008)

Review Biochemistry & Molecular Biology

A beta Oligomers - a decade of discovery

Dominic M. Walsh et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Neurosciences

Evidence for entorhinal and parietal cortices involvement in path integration in the rat

C Parron et al.

EXPERIMENTAL BRAIN RESEARCH (2004)

Article Neurosciences

APP processing and synaptic function

F Kamenetz et al.

NEURON (2003)

Article Neurosciences

Protein kinase Mζ is necessary and sufficient for LTP maintenance

DSF Ling et al.

NATURE NEUROSCIENCE (2002)