期刊
NEUROBIOLOGY OF AGING
卷 101, 期 -, 页码 221-223出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.01.020
关键词
Aging; Brain-derived neurotrophic factor; Depression; Platelet
资金
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF) [16SV5536K, 16SV5537, 16SV5538, 16SV5837, 01UW0808, 01GL1716A, 01GL1716B]
- Max Planck Institute for Human Development, Berlin, Germany
- Deutsche Forschungsgemeinschaft [Exc257, KR 2956/4-1, GE 2576/2-1]
- Bundesministerium fur Bildung und Forschung (CSB)
- van Geest Cardiovascular Development Fund
- German Center for Neurodegenerative Diseases (DZNE)
- German Center for Cardiovascular Research (DZHK)
- Corona Foundation
The study found no significant effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations, but identified a positive correlation between platelet counts and BDNF levels. There was no significant relationship between Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score with BDNF levels.
Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60-85 years], 481 individuals from the younger-age reference group [22-37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study. (c) 2021 Elsevier Inc. All rights reserved.
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