期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 37, 期 12, 页码 2314-2326出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfab070
关键词
apela; apelin; apelin receptor; kidney; water homeostasis
资金
- Fonds Wetenschappelijk Onderzoek Vlaanderen [1702419N]
The apelinergic system plays an important role in renal and cardiovascular physiology and disease, primarily by regulating water homeostasis and blood pressure. It interacts with vasopressin and the renin-angiotensin system and has implications for various pathological states. Metabolically stable apelin analogues have also been developed with potential therapeutic applications.
The apelinergic system (AS) is a novel pleiotropic system with an essential role in renal and cardiovascular physiology and disease, including water homeostasis and blood pressure regulation. It consists of two highly conserved peptide ligands, apelin and apela, and a G-protein-coupled apelin receptor. The two ligands have many isoforms and a short half-life and exert both similar and divergent effects. Vasopressin, apelin and their receptors colocalize in hypothalamic regions essential for body fluid homeostasis and interact at the central and renal levels to regulate water homeostasis and diuresis in inverse directions. In addition, the AS and renin-angiotensin system interact both systemically and in the kidney, with implications for the cardiovascular system. A role for the AS in diverse pathological states, including disorders of sodium and water balance, hypertension, heart failure, pre-eclampsia, acute kidney injury, sepsis and diabetic nephropathy, has recently been reported. Furthermore, several metabolically stable apelin analogues have been developed, with potential applications in diverse diseases. We review here what is currently known about the physiological functions of the AS, focusing on renal, cardiovascular and metabolic homeostasis, and the role of the AS in associated diseases. We also describe several hurdles and research opportunities worthy of the attention of the nephrology community.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据