4.5 Review

Systemic and organ-specific immune-related manifestations of COVID-19

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Review Hematology

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

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Summary: This review compares the clinical features, diagnosis, and treatment approaches of COVID-CSS with other hematological CSS, emphasizing novel therapeutics targeting cytokines and cell signaling pathways. Comparison of inflammation markers and cytokine levels aims to establish a foundation for future diagnostic criteria of COVID-CSS.

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COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult

Sabrina Sokolovsky et al.

Summary: This case report describes a 36-year-old woman with a complete phenotype of Kawasaki Disease, who also had a history of COVID-19 infection, resembling the Multisystem Inflammatory Syndrome in Children (MIS-C). The findings suggest that a virulent strain of SARS-CoV-2 may cause a post-infectious inflammatory syndrome similar to Kawasaki Disease in adults, as well as children.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

Article Dermatology

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series

C. M. Magro et al.

Summary: COVID-19-related perniosis represents an exaggerated immune reaction triggered by the virus with significant type I interferon signaling, which is crucial for SARS-CoV-2 eradication and may lead to a more generalized highly inflammatory response. In the thrombotic retiform purpura of critically ill patients with COVID-19, vascular thrombosis in the skin and other organ systems is associated with a minimal interferon response, allowing excessive viral replication and release of viral proteins that trigger extensive complement activation in extrapulmonary endothelium.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Letter Medicine, General & Internal

High frequency of antiphospholipid antibodies in critically ill COVID-19 patients: a link with hypercoagulability?

M. Pineton de Chambrun et al.

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Article Virology

Clinical neurophysiology and cerebrospinal liquor analysis to detect Guillain-Barre syndrome and polyneuritis cranialis in COVID-19 patients: A case series

Paolo Manganotti et al.

Summary: Peripheral nervous system involvement, including polyradiculoneuritis and cranial polyneuritis, may occur in patients with COVID-19, and can be successfully treated with immunoglobulin therapy.

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Article Clinical Neurology

Immune-mediated neurological syndromes in SARS-CoV-2-infected patients

Antoine Guilmot et al.

Summary: Evidence of immune-mediated neurological syndromes in COVID-19 patients is limited. However, this study found that in a small subset of patients with neurological manifestations, CSF pleocytosis and detection of anti-GD1b and anti-Caspr2 antibodies may suggest secondary autoimmunity potentially induced by SARS-CoV-2 infection.

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Article Infectious Diseases

Follow-up of adults with noncritical COVID-19 two months after symptom onset

Claudia Carvalho-Schneider et al.

Summary: In noncritical COVID-19 patients, most individuals continued to experience symptoms up to 2 months after symptom onset, with the main complaints being anosmia/ageusia, dyspnoea, or asthenia. Factors associated with persistent symptoms included age 40-60 years old, hospital admission, and abnormal auscultation at symptom onset.

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Article Clinical Neurology

Cytokine release syndrome-associated encephalopathy in patients with COVID-19

P. Perrin et al.

Summary: This study found that patients with COVID-19 can develop a range of neurological manifestations, including various symptoms and laboratory abnormalities, with brain magnetic resonance imaging showing different brain abnormalities. Treatment with corticosteroids and intravenous immunoglobulins may help in the rapid recovery from neurological disturbances.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Acute adrenal infarction as an incidental CT finding and a potential prognosis factor in severe SARS-CoV-2 infection: a retrospective cohort analysis on 219 patients

Pierre Leyendecker et al.

Summary: Acute adrenal infarction is frequent in severe COVID-19 patients and may be a sign of poor prognosis, with higher ICU admission rates and longer hospital stays but similar mortality rates compared to patients without adrenal infarction.

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Thyroid Function Analysis in 50 Patients with COVID-19: A Retrospective Study

Min Chen et al.

Summary: This study found that levels of TSH and TT3 in COVID-19 patients were significantly lower compared to healthy controls and non-COVID-19 pneumonia patients, with a positive correlation between the severity of COVID-19 and the decrease in TSH and TT3 levels.

THYROID (2021)

Review Clinical Neurology

Guillain-Barre syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

Samir Abu-Rumeileh et al.

Summary: This study systematically reviewed 73 cases of GBS associated with COVID-19 reported in publications until July 2020. Most patients developed GBS manifestations after COVID-19 infection, with a majority showing good prognosis, and a male predominance was observed.

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Review Cardiac & Cardiovascular Systems

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

Carsten Tschoepe et al.

Summary: Inflammatory cardiomyopathy is a disease characterized by inflammatory cell infiltration into the myocardium and is predominantly mediated by viral infection. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis. The relative roles of the pathogen, host genomics and environmental factors in disease progression and healing are still under discussion.

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Article Cardiac & Cardiovascular Systems

Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

Israel Valverde et al.

Summary: The study documented cardiovascular clinical findings, cardiac imaging, and laboratory markers in children with multisystem inflammatory syndrome associated with COVID-19 infection. Most children in the study cohort had cardiac complications and significantly raised levels of inflammatory markers.

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COVID-19 and acute pancreatitis: examining the causality

Enrique de-Madaria et al.

Summary: There is reported association between acute pancreatitis and COVID-19 as SARS-CoV-2 receptors are expressed in the pancreas. Despite biases, further investigation is necessary to explore this hypothesis.

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Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg et al.

Summary: This study found distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts showed a broader range of antibody responses, while children predominantly generated antibodies specific for the S protein and had reduced neutralizing activity compared to adults.

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Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

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Feng Pan et al.

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Hematological findings and complications of COVID-19

Evangelos Terpos et al.

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Jean M. Connors et al.

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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

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Transcriptional and Cellular Diversity of the Human Heart

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Atypical erythema nodosum in a patient withCOVID-19 pneumonia

Lucia Ordieres-Ortega et al.

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Abnormal pulmonary function in COVID-19 patients at time of hospital discharge

Xiaoneng Mo et al.

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Secondary hemophagocytic lymphohistiocytosis, HScore and COVID-19

Giuseppe G. Loscocco

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CT imaging features of 4121 patients with COVID-19: A meta-analysis

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Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries

Esther E. Freeman et al.

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'Toxic erythema' and eosinophilia associated with tocilizumab therapy in a COVID-19 patient

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Letter Dermatology

Coronavirus 19 presenting with atypical Sweet's syndrome

B. Taskin et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Letter Hematology

Response to Lupus anticoagulant is frequent in patients with Covid-19 (JTH-2020-00483)

Ning Tang

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Letter Hematology

Lupus anticoagulant is frequent in patients with Covid-19

Ines Harzallah et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Is the HScore useful in COVID-19?

David L. Leverenz et al.

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Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

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Article Critical Care Medicine

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

Sharon E. Fox et al.

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Immune-related adverse events of checkpoint inhibitors

Manuel Ramos-Casals et al.

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Article Clinical Neurology

Miller Fisher syndrome and polyneuritis cranialis in COVID-19

Consuelo Gutierrez-Ortiz et al.

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Neurologic manifestations in hospitalized patients with COVID-19 The ALBACOVID registry

Carlos Manuel Romero-Sanchez et al.

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Letter Medicine, General & Internal

Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19

Louise Bowles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Characterization of the Inflammatory Response to Severe COVID-19 Illness

Oliver J. McElvaney et al.

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Letter Medicine, General & Internal

Myasthenia Gravis Associated With SARS-CoV-2 Infection

Domenico A. Restivo et al.

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Maculopapular eruptions associated toCOVID-19: A subanalysis of theCOVID-Pielstudy

Alba Catala et al.

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Thyrotoxicosis in patients with COVID-19: the THYRCOV study

Andrea Lania et al.

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Early CT features and temporal lung changes in COVID-19 pneumonia in Wuhan, China

Qiongjie Hu et al.

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Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19

Margot Combet et al.

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Letter Respiratory System

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Justine Frija-Masson et al.

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Secondary HLH is uncommon in severe COVID-19

Henry Wood et al.

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Ahmed Dirweesh et al.

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Evaluation of Chilblains as a Manifestation of the COVID-19 Pandemic

Anne Herman et al.

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Is a Cytokine Storm Relevant to COVID-19?

Pratik Sinha et al.

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Anticardiolipin IgG autoantibody level is an independent risk factor for COVID-19 severity

Daniel Bertin et al.

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COVID-19 interstitial pneumonia: monitoring the clinical course in survivors

Ganesh Raghu et al.

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Coagulation abnormalities and thrombosis in patients with COVID-19

Marcel Levi et al.

LANCET HAEMATOLOGY (2020)

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Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020

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Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases

Diana Lindner et al.

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Clyde W. Yancy et al.

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Images in Practice: Painful Cutaneous Vasculitis in a SARS-Cov-2 IgG-Positive Child

Alfonso Papa et al.

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The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Esther E. Freeman et al.

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Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection

Anuradha Lala et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Cutaneous manifestations in SARS-CoV-2 infection (COVID-19): a French experience and a systematic review of the literature

S. Matar et al.

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Concurrent chilblains and retinal vasculitis in a child with COVID-19

L. Quintana-Castanedo et al.

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Retiform purpura as a dermatological sign of coronavirus disease 2019 (COVID-19) coagulopathy

X. Bosch-Amate et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Relapsing symmetric livedo reticularis in a patient with COVID-19 infection

M. Verheyden et al.

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Lupus anticoagulant is frequent in patients with Covid‐19: Response to Reply

Inès Harzallah et al.

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Antiphospholipid antibodies in patients with COVID-19: A relevant observation?

Katrien M. J. Devreese et al.

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SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Alexis Werion et al.

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An adult with Kawasaki-like multisystem inflammatory syndrome associated with COVID-19

Sheila Shaigany et al.

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Neurological associations of COVID-19

Mark A. Ellul et al.

LANCET NEUROLOGY (2020)

Article Biochemistry & Molecular Biology

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Camila Rosat Consiglio et al.

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COVID-19-associated Guillain-Barresyndrome: The early pandemic experience

James B. Caress et al.

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Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

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Editorial Material Cardiac & Cardiovascular Systems

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Peter Chin-Hong et al.

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in US Children and Adolescents

Leora R. Feldstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in Children in New York State

Elizabeth M. Dufort et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features

Petra Zimmermann et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

Letter Cardiac & Cardiovascular Systems

Cardiac Magnetic Resonance Characterization of Myocarditis-Like Acute Cardiac Syndrome in COVID-19

Antonio Esposito et al.

JACC-CARDIOVASCULAR IMAGING (2020)

Editorial Material Medicine, General & Internal

WHEN WILL WE BE WELL AGAIN? Covid-19 and chronic fatigue

Frances M. K. Williams et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Editorial Material Medicine, General & Internal

Long term respiratory complications of covid-19

Emily Fraser

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Global evaluation of echocardiography in patients with COVID-19

Marc R. Dweck et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2020)

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Coronavirus Disease 2019 (COVID-19) CT Findings: A Systematic Review and Meta-analysis

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Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS CoV-2

Caroline Diorio et al.

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An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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COVID-19 can affect the heart

Eric J. Topol

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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

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Editorial Material Critical Care Medicine

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Lorraine B. Ware

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SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome

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Erythema nodosum as a cutaneous manifestation of COVID-19 infection

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BMJ CASE REPORTS (2020)

Article Multidisciplinary Sciences

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Kevin W. Ng et al.

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COVID-19 and multisystem inflammatory syndrome in children and adolescents

Li Jiang et al.

LANCET INFECTIOUS DISEASES (2020)

Article Medicine, General & Internal

Adrenal insufficiency in coronavirus disease 2019: a case report

Maryam Heidarpour et al.

JOURNAL OF MEDICAL CASE REPORTS (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Association between Initial Chest CT or Clinical Features and Clinical Course in Patients with Coronavirus Disease 2019 Pneumonia

Zhe Liu et al.

KOREAN JOURNAL OF RADIOLOGY (2020)

Article Medicine, General & Internal

Symptoms of Pleurisy as the Initial Presentation of COVID-19

Christopher Oleynick

AMERICAN JOURNAL OF CASE REPORTS (2020)

Letter Biochemistry & Molecular Biology

Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

Li Tan et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Critical Care Medicine

Phenotypes in acute respiratory distress syndrome: moving towards precision medicine

Pratik Sinha et al.

CURRENT OPINION IN CRITICAL CARE (2019)

Review Pharmacology & Pharmacy

Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry)

Marta Perez-De-Lis et al.

EXPERT OPINION ON DRUG SAFETY (2017)

Review Gastroenterology & Hepatology

Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection

Manuel Ramos-Casals et al.

JOURNAL OF HEPATOLOGY (2017)

Review Immunology

Kawasaki disease in adults: Observations in France and literature review

Jean-Baptiste Fraison et al.

AUTOIMMUNITY REVIEWS (2016)

Review Medicine, General & Internal

Guillain-Barre syndrome

Hugh J. Willison et al.

LANCET (2016)

Article Cardiac & Cardiovascular Systems

Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population

Kevin G. Friedman et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Pediatrics

Concurrent Respiratory Viruses and Kawasaki Disease

Jessica L. Turnier et al.

PEDIATRICS (2015)

Article Medicine, General & Internal

Adult haemophagocytic syndrome

Manuel Ramos-Casals et al.

LANCET (2014)

Review Immunology

Regulation of type I interferon responses

Lionel B. Ivashkiv et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Review Hematology

Clinical course of high-risk patients diagnosed with antiphospholipid syndrome

V. Pengo et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

Review Immunology

Immunity and immunopathology to viruses: what decides the outcome?

Barry T. Rouse et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Medical Progress: Myocarditis.

Leslie T. Cooper

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Article Medicine, General & Internal

A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia

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AMERICAN JOURNAL OF MEDICINE (2008)

Article Pediatrics

Kawasaki disease in a pediatric intensive care unit: A case-control study

Samuel R. Dominguez et al.

PEDIATRICS (2008)

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HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

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PEDIATRIC BLOOD & CANCER (2007)