4.7 Review

Advances in immunotherapy for hepatocellular carcinoma

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Summary: This study analyzed the radiological response in 31 hepatocellular carcinoma patients treated with nivolumab, finding heterogeneous imaging findings both between and within patients. Disease progression does not always indicate treatment failure, and surrogate end-points may not accurately reflect survival outcomes.

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AASLD guidelines for the treatment of hepatocellular carcinoma

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Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

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Trial Watch: Toll-like receptor agonists in cancer immunotherapy

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Impact of oncogenic pathways on evasion of antitumour immune responses

Stefani Spranger et al.

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Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma

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Elements of cancer immunity and the cancer-immune set point

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An immunogenic personal neoantigen vaccine for patients with melanoma

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The immune contexture in cancer prognosis and treatment

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Cytokines for the induction of antitumor effectors: The paradigm of Cytokine-Induced Killer (CIK) cells

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Liver macrophages in tissue homeostasis and disease

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Targeting neoantigens to augment antitumour immunity

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Applications of Immunogenomics to Cancer

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Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Developments in cancer vaccines for hepatocellular carcinoma

Luigi Buonaguro

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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

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Management of toxicities of immune checkpoint inhibitors

Lavinia Spain et al.

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Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial

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Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma

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Josep M. Llovet et al.

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Tumor-infiltrating lymphocyte activity is enhanced in tumors with low IL-10 production in HBV-induced hepatocellular carcinoma

Yang Shi et al.

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Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

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Oxana V. Makarova-Rusher et al.

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

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Ton N. Schumacher et al.

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Enhanced suppressor function of TIM-3+FoxP3+ regulatory T cells

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EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

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Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib

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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

Pierre G. Coulie et al.

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HLA ligandome tumor antigen discovery for personalized vaccine approach

Hans-Georg Rammensee et al.

EXPERT REVIEW OF VACCINES (2013)

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Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

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Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

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Improved affinity AFP-specific T cell receptor for hepatocellular carcinoma

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Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen et al.

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Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence

Hiroteru Kamimura et al.

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Human CCR4+CCR6+Th17 Cells Suppress Autologous CD8+ T Cell Responses

Fei Zhao et al.

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Cross-Presentation of Antigen by Diverse Subsets of Murine Liver Cells

Mohammad R. Ebrahimkhani et al.

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Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

Robert D. Schreiber et al.

SCIENCE (2011)

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Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity

Nitya Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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The Liver as a Lymphoid Organ

Ian Nicholas Crispe

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Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats

Thomas Reiberger et al.

JOURNAL OF HEPATOLOGY (2009)

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Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

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A small molecule-kinase interaction map for clinical kinase inhibitors

MA Fabian et al.

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Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma

M Ritter et al.

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P Matzinger

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PD-L2 is a second ligand for PD-I and inhibits T cell activation

Y Latchman et al.

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