期刊
NATURE REVIEWS ENDOCRINOLOGY
卷 17, 期 6, 页码 336-349出版社
NATURE PORTFOLIO
DOI: 10.1038/s41574-021-00488-z
关键词
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资金
- Canadian Institutes of Health Research
- Federation Hospitalo-Universitaire DDS-Paris Net
- ANR Hyposkel
- Fondazione Italiana Ricerca sulle Malattie dell'Osso
- Wellcome Trust Investigator Award
- National Institute for Health Research (NIHR) Senior Investigator Award
- NIHR Oxford Biomedical Research Centre Programme
- Menarini Foundation
The major mineralized tissues, bone and teeth, share mechanisms governing their development and mineralization, including hormonal regulation and gene control. Systemic disorders and treatments can affect both bone and teeth similarly, with teeth experiencing more permanent effects due to lack of remodeling after formation. Understanding these shared mechanisms is crucial for screening and treating disorders affecting both bone and teeth.
The major mineralized tissues are bone and teeth, which share several mechanisms governing their development and mineralization. This crossover includes the hormones that regulate circulating calcium and phosphate concentrations, and the genes that regulate the differentiation and transdifferentiation of cells. In developing endochondral bone and in developing teeth, parathyroid hormone-related protein (PTHrP) acts in chondrocytes to delay terminal differentiation, thereby increasing the pool of precursor cells. Chondrocytes and (in specific circumstances) pre-odontoblasts can also transdifferentiate into osteoblasts. Moreover, bone and teeth share outcomes when affected by systemic disorders of mineral homeostasis or of the extracellular matrix, and by adverse effects of treatments such as bisphosphonates and fluoride. Unlike bone, teeth have more permanent effects from systemic disorders because they are not remodelled after they are formed. This Review discusses the normal processes of bone and tooth development, followed by disorders that have effects on both bone and teeth, versus disorders that have effects in one without affecting the other. The takeaway message is that bone specialists should know when to screen for dental disorders, just as dental specialists should recognize when a tooth disorder should raise suspicions about a possible underlying bone disorder. Several shared mechanisms govern the development of bone and teeth. This Review summarizes these shared pathways and discusses the disorders that are related to both bone and teeth.
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