期刊
NATURE NEUROSCIENCE
卷 24, 期 5, 页码 694-704出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-021-00820-w
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资金
- Biotechnology and Biological Sciences Research Council UK [BB/N00597X/1, BB/N006836/1]
- Medical Research Council UK [MC_UU_12024/3, MC_UU_00003/4]
- BBSRC [BB/N006836/1, BB/N00597X/1] Funding Source: UKRI
- MRC [MC_UU_12024/3, MC_UU_00003/4] Funding Source: UKRI
The study shows that millisecond-timescale neural coactivity plays a key role in encoding behavioral information and supporting memory retrieval. Coactivity among hippocampal CA1 neurons can discriminate short-lived behavioral contingencies independently of individual neuron tuning. Optogenetic suppression of inputs from the upstream CA3 region impairs coactivity-based contingency information and subsequent dynamic memory retrieval.
El-Gaby et al. combine multiunit recordings and optogenetic silencing in the mouse hippocampus and uncover a primary role for millisecond-timescale neural coactivity in encoding behavioral contingency information and supporting memory retrieval. Neural correlates of external variables provide potential internal codes that guide an animal's behavior. Notably, first-order features of neural activity, such as single-neuron firing rates, have been implicated in encoding information. However, the extent to which higher-order features, such as multineuron coactivity, play primary roles in encoding information or secondary roles in supporting single-neuron codes remains unclear. Here, we show that millisecond-timescale coactivity among hippocampal CA1 neurons discriminates distinct, short-lived behavioral contingencies. This contingency discrimination was unrelated to the tuning of individual neurons, but was instead an emergent property of their coactivity. Contingency-discriminating patterns were reactivated offline after learning, and their reinstatement predicted trial-by-trial memory performance. Moreover, optogenetic suppression of inputs from the upstream CA3 region during learning impaired coactivity-based contingency information in the CA1 and subsequent dynamic memory retrieval. These findings identify millisecond-timescale coactivity as a primary feature of neural firing that encodes behaviorally relevant variables and supports memory retrieval.
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