Wnt-β-catenin as an epigenetic switcher in colonic Treg cells

In the colonic environment, sustained Wnt-beta-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinflammatory ROR gamma t(+) T-reg cells, whose expansion parallels the disease progression from inflammatory bowel disease (IBD) to manifest colorectal cancer (CRC).

Automated summary

In the colonic environment, sustained Wnt-beta-catenin activation in regulatory T cells leads to epigenetic rewiring towards proinflammatory ROR gamma t(+) T-reg cells, whose expansion correlates with the progression from inflammatory bowel disease (IBD) to colorectal cancer (CRC).