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An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank

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Summary: The study evaluated the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank, identifying 1,857 loci associated with at least one trait. Through Mendelian randomization analysis, 51 causal relationships were discovered, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, by developing polygenic risk scores and building 'multi-PRS' models, genetic risk stratification for common diseases was improved.

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