4.8 Article

Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

H. Frangoul et al.

Summary: Research utilizing CRISPR-Cas9 technology for gene editing in patients with TDT and SCD showed high levels of edited alleles in bone marrow and blood, leading to partial or complete elimination of symptoms.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Multidisciplinary Sciences

The promise and challenge of therapeutic genome editing

Jennifer A. Doudna

NATURE (2020)

Article Multidisciplinary Sciences

Pan-cancer analysis of whole genomes

Peter J. Campbell et al.

NATURE (2020)

Article Biotechnology & Applied Microbiology

Single-cell analysis of structural variations and complex rearrangements with tri-channel processing

Ashley D. Sanders et al.

NATURE BIOTECHNOLOGY (2020)

Article Genetics & Heredity

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortes-Ciriano et al.

NATURE GENETICS (2020)

Article Multidisciplinary Sciences

CRISPR-engineered T cells in patients with refractory cancer

Edward A. Stadtmauer et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Mechanisms generating cancer genome complexity from a single cell division error

Neil T. Umbreit et al.

SCIENCE (2020)

Article Cell Biology

Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing

Isabel Weisheit et al.

CELL REPORTS (2020)

Article Genetics & Heredity

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Oana M. Enache et al.

NATURE GENETICS (2020)

Article Genetics & Heredity

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

John Maciejowski et al.

NATURE GENETICS (2020)

Article Biochemistry & Molecular Biology

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Michael Zuccaro et al.

Article Medicine, Research & Experimental

BCL11A enhancer edited hematopoietic stem cells persist in rhesus monkeys without toxicity

Selami Demirci et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Medicine, Research & Experimental

Allele-specific genome targeting in the development of precision medicine

Junjiao Wu et al.

THERANOSTICS (2020)

Review Biochemistry & Molecular Biology

Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases

Daesik Kim et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Biochemistry & Molecular Biology

Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin

Kez Cleal et al.

GENOME RESEARCH (2019)

Article Biochemistry & Molecular Biology

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Yuxuan Wu et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

Gregoire Cullot et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Pan-cancer whole-genome analyses of metastatic solid tumours

Peter Priestley et al.

NATURE (2019)

Article Multidisciplinary Sciences

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone et al.

NATURE (2019)

Review Medicine, Research & Experimental

Emerging Genetic Therapy for Sickle Cell Disease

Stuart H. Orkin et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

Article Biochemistry & Molecular Biology

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

Morgan L. Maeder et al.

NATURE MEDICINE (2019)

Article Hematology

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Jean-Yves Metais et al.

BLOOD ADVANCES (2019)

Article Multidisciplinary Sciences

CRIS.py: A Versatile and High-throughput Analysis Program for CRISPR-based Genome Editing

Jon P. Connelly et al.

SCIENTIFIC REPORTS (2019)

Article Cell Biology

Chromosomes trapped in micronuclei are liable to segregation errors

Mar Soto et al.

JOURNAL OF CELL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

Eva K. Brinkman et al.

MOLECULAR CELL (2018)

Article Biotechnology & Applied Microbiology

Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements

Michael Kosicki et al.

NATURE BIOTECHNOLOGY (2018)

Article Genetics & Heredity

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway

Chris D. Richardson et al.

NATURE GENETICS (2018)

Article Biochemistry & Molecular Biology

p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells

Robert J. Ihry et al.

NATURE MEDICINE (2018)

Article Biochemistry & Molecular Biology

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response

Emma Haapaniemi et al.

NATURE MEDICINE (2018)

Article Medicine, Research & Experimental

A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for beta-Hemoglobinopathies

Olivier Humbert et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)

Letter Multidisciplinary Sciences

Inter-homologue repair in fertilized human eggs?

Dieter Egli et al.

NATURE (2018)

Letter Multidisciplinary Sciences

Large deletions induced by Cas9 cleavage

Fatwa Adikusuma et al.

NATURE (2018)

Article Multidisciplinary Sciences

Nuclear envelope assembly defects link mitotic errors to chromothripsis

Shiwei Liu et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

Jeroen van den Berg et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemical Research Methods

Efficient scarless genome editing in human pluripotent stem cells

Kazuya Ikeda et al.

NATURE METHODS (2018)

Review Genetics & Heredity

Base editing: precision chemistry on the genome and transcriptome of living cells

Holly A. Rees et al.

NATURE REVIEWS GENETICS (2018)

Article Multidisciplinary Sciences

Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage

Nicole M. Gaudelli et al.

NATURE (2017)

Article Multidisciplinary Sciences

Correction of a pathogenic gene mutation in human embryos

Hong Ma et al.

NATURE (2017)

Review Cell Biology

Telomeres in cancer: tumour suppression and genome instability

John Maciejowski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Cell Biology

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

Peter Ly et al.

TRENDS IN CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

Ha Youn Shin et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

Andres Canela et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Daniel P. Dever et al.

NATURE (2016)

Article Multidisciplinary Sciences

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor et al.

NATURE (2016)

Article Multidisciplinary Sciences

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos

Cayetana Vazquez-Diez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Cell Biology

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

Mark A. DeWitt et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Genetics & Heredity

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

Mitchell L. Leibowitz et al.

ANNUAL REVIEW OF GENETICS, VOL 49 (2015)

Article Biochemistry & Molecular Biology

Chromothriptic Cure of WHIM Syndrome

David H. McDermott et al.

Article Biochemistry & Molecular Biology

Chromothripsis and Kataegis Induced by Telomere Crisis

John Maciejowski et al.

Article Multidisciplinary Sciences

Replication stress activates DNA repair synthesis in mitosis

Sheroy Minocherhomji et al.

NATURE (2015)

Article Multidisciplinary Sciences

Chromothripsis from DNA damage in micronuclei

Cheng-Zhong Zhang et al.

NATURE (2015)

Article Multidisciplinary Sciences

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Matthew C. Canver et al.

NATURE (2015)

Review Reproductive Biology

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos

Kristin M. Whitworth et al.

BIOLOGY OF REPRODUCTION (2014)

Review Biochemistry & Molecular Biology

Development and Applications of CRISPR-Cas9 for Genome Engineering

Patrick D. Hsu et al.

Article Biochemistry & Molecular Biology

Criteria for Inference of Chromothripsis in Cancer Genomes

Jan O. Korbel et al.

Article Biochemistry & Molecular Biology

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

Emily M. Hatch et al.

Review Biochemistry & Molecular Biology

Regulation of telomere addition at DNA double-strand breaks

Cyril Ribeyre et al.

CHROMOSOMA (2013)

Article Cell Biology

Chromothripsis in congenital disorders and cancer: similarities and differences

Wigard P. Kloosterman et al.

CURRENT OPINION IN CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

DNA breaks and chromosome pulverization from errors in mitosis

Karen Crasta et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens et al.

Article Multidisciplinary Sciences

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Peter J. Campbell et al.

NATURE (2010)

Article Genetics & Heredity

DNA lesions sequestered in micronuclei induce a local defective-damage response

Mariona Terradas et al.

DNA REPAIR (2009)

Article Biochemistry & Molecular Biology

Resolution of anaphase bridges in cancer cells

DR Hoffelder et al.

CHROMOSOMA (2004)

Article Biochemistry & Molecular Biology

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks

JM Stark et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)