A stop sign for RAS trafficking

N-Ras lipidation cycling is known to regulate its trafficking and function. A new S-depalmitoylation inhibitor induces N-Ras membrane mislocalization, providing insights into N-Ras function and laying the foundation for a new cancer therapeutic strategy.

Automated summary

The lipidation cycling of N-Ras is crucial for its trafficking and function, and a novel S-depalmitoylation inhibitor has been found to induce membrane mislocalization of N-Ras, shedding light on its function and potentially paving the way for a new cancer therapeutic strategy.