PHF7 directs cardiac reprogramming

Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.

Automated summary

The histone reader PHF7 has been shown to enhance cardiac reprogramming by recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers, surmounting epigenetic barriers.