Monocyte and dendritic cell defects in COVID-19

Monocytes, plasmacytoid and conventional dendritic cells are crucial for antiviral immune responses. A new study now compares severe and moderate cases of COVID-19 and links defects in viral sensing, interferon and antigen presentation pathways, associated with upregulated apoptosis and inflammatory pathways, to high COVID-19 severity.

Automated summary

A new study compares severe and moderate cases of COVID-19 and finds a link between defects in viral sensing, interferon and antigen presentation pathways, as well as upregulated apoptosis and inflammatory pathways, to high COVID-19 severity.