4.8 Article

Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease

期刊

NATURE BIOTECHNOLOGY
卷 39, 期 9, 页码 1078-+

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41587-021-00897-5

关键词

-

资金

  1. NIH [UH3NS100544]

向作者/读者索取更多资源

The use of an implantable two-way neural interface enables wireless neural monitoring and stimulation for up to 15 months following implantation. This technological approach may have wide applicability to brain disorders treatable by invasive neuromodulation.
Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson's disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation. An implanted device in the brain enables wireless neural monitoring and stimulation for up to 15 months following implantation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据