Revolutionary view of two ways to split a mitochondrion

Review Multidisciplinary Sciences

Function and regulation of the divisome for mitochondrial fission

Felix Kraus et al.

Summary: Mitochondria form dynamic networks through fusion and fission events, with fission serving as an endpoint event in signaling axis for cells to sense and respond to external cues. The fission process is coordinated by membrane-associated adaptors, influenced by organellar and cytoskeletal interactions, and executed by the GTPase DRP1. Separating the functional and regulatory aspects of the 'mitochondrial divisome' into core and accessory machinery provides a mechanistic understanding of the mitochondrial fission process.

NATURE (2021)

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Article Cell Biology

NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation

Cory L. Simpson et al.

Summary: This study reveals that regulated breakdown of mitochondria is critical for epidermal development, with keratinocytes in the upper layers initiating mitochondrial fragmentation, depolarization, and acidification. The mitophagy receptor NIX and DRP1 play essential roles in driving epidermal morphogenesis by promoting mitochondrial degradation in the terminal differentiation of keratinocytes.

CELL REPORTS (2021)

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Article Multidisciplinary Sciences

Distinct fission signatures predict mitochondrial degradation or biogenesis

Tatjana Kleele et al.

Summary: Mitochondrial fission is a highly regulated process that can impact cell function and health. Depending on the location and manner of division, mitochondria can be divided into two types, one for clearing damaged material and undergoing mitophagy, and the other for mitochondrial proliferation.

NATURE (2021)

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Article Cell Biology