Acroquinolones A and B, two polyphenolic isoprenylated acetophenone-quinolone hybrids with anti-proliferative activities from Acronychia pedunculata (L.) Miq

Two new compounds belonging to a new class of acetophenone-alkaloid hybrids, acroquinolones A (1a) and B (1b), together with six known compounds, were isolated from the leaves of Acronychia pedunculata (L.) Miq. Their structures contain a quinolone and an acetophenone fragment, connected through an isopentyl unit. Attempts to isolate more hybrids from another sample collected at the same location but during a different season led to the isolation of a new tocopherol (2). The new compounds were evaluated against several cancer cell lines.

Automated summary

Two new acetophenone-alkaloid hybrids, acroquinolones A and B, along with six known compounds, were isolated from leaves of Acronychia pedunculata. A new tocopherol was also isolated from a sample collected at the same location but during a different season. The new compounds were evaluated against cancer cell lines.