Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih

Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known lignans, erythro-(7S,8R)-guaiacyl-glycerol-beta-O-4 '-dihydroconiferyl ether (3), threo-(7R, 8R)-1- (4- hydroxy- 3- methoxyphenyl) - 2-{4-[(E)- 3- hydroxy- 1- propen yl) ]- 2- methoxyphenoxy}-1, 3- propanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinsepiol (9), medioresinol (10), (+)-pinoresinol (11), 2 alpha-guaicyl-4-oxo-6 alpha-catechyl-3,7-dioxabicyclo [3.3.0]octane (12), cycloolivil (13), isolariciresinol (14) were isolated from Dolomiaea souliei (Franch.) C.Shih. Their structures were determined by UV, CD, HR-ESI-TOFMS, 1 D and 2 D NMR experiments. Their hepatoprotective effect against LPS-induced L-02 cells injury was also studied. Result revealed that compound 4 showed best protective effect on LPS-induced L-02 cells. [GRAPHICS] .

Automated summary

Two new neolignans, dolominol A and dolominol B, along with 12 known lignans, were isolated from Dolomiaea souliei. Their structures were determined and their hepatoprotective effect against LPS-induced L-02 cells injury was studied, with compound 4 showing the best protective effect.