期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 11, 页码 2713-2721出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1917571
关键词
Laurencia obtusa; Red Sea; Penicillium aculeatum; antimicrobial; cytotoxicity
资金
- Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah [G: 552-150-1441]
Two new sulfonyl metabolites, pensulfonoxy and pensulfonamide, along with four known metabolites were isolated from the endophytic fungus Penicillium aculeatum, showing potent antibacterial and antifungal activities against Escherichia coli and Candida albicans, respectively. Additionally, compound 2 exhibited significant preferential cytotoxicity against MCF-7 cells compared to compound 1 and the drug control, paclitaxel.
Two new sulfonyl metabolites, pensulfonoxy (1) and pensulfonamide (2), together with four known metabolites were obtained from the fermentation extract of Penicillium aculeatum, an endophytic fungus isolated from the marine red alga Laurencia obtusa. The structures of the compounds were established on the basis of extensive NMR and MS spectroscopic analysis. The ethyl acetate extract exhibited potent antibacterial inhibitory activity against Escherichia coli, while compound 2 exhibited antifungal activity against Candida albicans with inhibition diameters of 20.5 and 18.0 mm, respectively. Moreover, compound 2 also displayed the most potent preferential cytotoxicity against MCF-7, while compound 1 displayed relatively mild activity against HCT-116 with IC50 values of 2.18 and 5.23 mu M, respectively, compared to the drug control, paclitaxel.
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