期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 19, 页码 5022-5031出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1917572
关键词
Porifera; Aaptos aaptos; aaptosvanphong; aaptamine alkaloid; cytotoxic activity
资金
- Vietnam Academy of Science and Technology [T-DDLB0.01/20-22]
Four new aaptamine alkaloids were isolated from the sponge Aaptos, showing significant cytotoxic effects against various cancer cell lines. One of the compounds exhibited the most potent cytotoxic activity among them.
Four new aaptamine alkaloids, named as 9-methoxy-N-demethylaaptanone (1), 3,5-dicarbomethoxy-1, 6- naphthyridine (2), aaptosvanphongs A and B (3 and 4), and three known aaptamine alkaloids as 2-methoxy-3-oxoaaptamine (5), 8,9,9-trimethoxy-9H-benzo[de][1,6]-naphthyridine (6), and demethyl(oxy)aaptamine (7) were isolated from the sponge Aaptos by various chromatographic methods. Their structures were established by extensive spectroscopic analyses (HR-ESI-MS, 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds 1-7 significantly showed cytotoxic effects against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values in range from 7.7 +/- 0.8 to 51.4 +/- 1.8 mu M. Among them, compound 7 exhibited the most cytotoxic activity with corresponding IC50 values of 9.2 +/- 1.0, 7.8 +/- 0.6, 8.4 +/- 0.8, and 7.7 +/- 0.8 mu M.
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