期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 15, 页码 3931-3937出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1900844
关键词
Camellia sinensis var; assamica; dihydrostilbene; cytotoxic activity
资金
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2018.09]
Three undescribed dihydrostilbene glycosides and seven known compounds were isolated from the methanol extract of Camellia sinensis var. assamica leaves. All compounds exhibited cytotoxic activity against human oral cancer and human breast cancer cell lines. Compound 10 showed significant cytotoxic activity compared to the positive control capecitabine.
Three undescribed dihydrostilbene glycosides, 3,5-dihydroxyldihydrostilbene 4 '-O-[6 ''-O-(4 '''-hydroxylbenzoyl)]-beta-D-glucopyranoside (1), 3,5-dihydroxyldihydrostilbene 4 '-O-(6 ''-O-galloyl)-beta-D-glucopyranoside (2), and 3,5-dihydroxyldihydrostilbene 4 '-O-[6 ''-O-(3 ''',4 '''-dimethoxyl)galloyl]-beta-D-glucopyranoside (3), and seven known compounds, kaempferol 3-O-beta-D-glucopyranoside (4), isoquercitrin (5), kaempferol 3-O-alpha-L-rhamnoside (6), quercitrin (7), (6S,9R)-roseoside (8), (-)-epicatechin 3-O-gallate (9), and (-)-epigallocatechin 3-O-gallate (10) have been isolated from the methanol extract of the leaves of Camellia sinensis var. assamica (J.W.Mast.) Kitam. (synnonym of Camellia assamica (Mast.) H.T.Chang) (Theaceae). Their structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. All compounds were evaluated for cytotoxic activity against human oral cancer (CAL27) and human breast cancer (MDAMB231) cell lines. Compound 10 showed significant cytotoxic activity against CAL27 and MDAMB231 cell lines with IC50 values of 9.78 +/- 0.25 and 3.27 +/- 0.18 mu M, respectively, compared to those of positive control, capecitabine (IC50 values of 8.20 +/- 0.75 and 5.20 +/- 0.89 mu M).
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