期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 11, 页码 2783-2790出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1927024
关键词
Meliaceae; Carapa procera; triterpenoids; limonoids; cytotoxicity
资金
- SNF (Swiss National Foundation) [IZSEZ0_177640/1, IZSEZO_180383/1]
- DAAD (German Academic Service Exchange) [57314019]
- Swiss National Science Foundation (SNF) [IZSEZ0_177640] Funding Source: Swiss National Science Foundation (SNF)
The phytochemical study of Carapa procera DC's stem bark extract led to the isolation of a new natural limonoid, along with seven known compounds. The cytotoxicity of these compounds was evaluated on human lung adenocarcinoma A549 and Raw 264.7 mouse macrophage cell lines, with obacunone showing the most potent effect against both cell lines. These results suggest that limonoid derivatives could be promising sources of natural bioactive metabolites against cancer.
The phytochemical study of the CH2Cl2- MeOH (1:1, v/v) extract of the stem bark of Carapa procera DC (Meliaceae) led to the isolation and characterisation of a new natural limonoid 7 beta-obacunol (6), along with seven known compounds. Their structures were elucidated by spectroscopic means, including 1 D and 2 D NMR, HRESI-MS and by comparison with published data. The cytotoxicity of compounds 1-6 was assessed in vitro by the WST-1 assay on human lung adenocarcinoma A549 and Raw 264.7 mouse macrophage cell lines. Results suggested that obacunone (3) exhibited the most potent cytotoxic effect against A549 and Raw 264.7 cells with respective IC50 values of 25.24 mu M and 29.14 mu M, while the new natural limonoid 7 beta-obacunol (6) exhibited 32.75 mu M and 39.19 mu M, respectively on both cell lines. Therefore, limonoid derivatives might be promising sources of natural bioactive metabolites against cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据