期刊
NANOTOXICOLOGY
卷 15, 期 6, 页码 761-778出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17435390.2021.1919329
关键词
Iron oxide nanoparticles; NAFLD; hepatic iron overload; BMP-SMAD; hepatic steatosis
资金
- National Basic Research Program [2016YFA0201603]
- National Natural Science Foundation of China [11775234, 11975251, 11875268]
- Open Project of Key Laboratory of Nanobiological Effects and Safety, CAS [NSKF202007]
- Research Foundation of Guangzhou First People's Hospital [KY09040029]
In patients with nonalcoholic fatty liver disease (NAFLD), iron oxide nanoparticles (IONPs) were found to exacerbate de novo lipogenesis, leading to hepatic iron overload and inflammation.
Nonalcoholic fatty liver disease (NAFLD) is the leading hepatic manifestation of metabolic syndrome worldwide, and is clinically accompanied by iron overload. As the increasing application of iron oxide nanoparticles (IONPs) on the imaging and diagnosis in NAFLD, the potential hepatic effect and mechanism of IONPs on NAFLD should be well studied. Here, we demonstrate that carboxyl-modified (COOH-IONPs) and amino-coated IONPs (NH2-IONPs) exhibit no significant hepatic toxicity in normal mice at the clinical injection dose, but aggravate SREBP-1c-mediated de novo lipogenesis (DNL) in the livers of mice with NAFLD induced by high-fat diet (HFD) and in HepG2 cells incubated with oleic acid (OA), especially in those treated by the positive NH2-IONPs. In the present study, mice receiving IONPs for 7 day show mild iron overload in the liver and exhibit enhanced hepatic inflammation in NAFLD. The BMP-SMAD pathway is initiated by hepatic iron overload and is aggravated in NAFLD. In conclusion, BMP-SMAD-mediated hepatic iron overload aggravated lipid accumulation in the liver and hepatic inflammatory responses, implying that effective measures in addition to hepatic iron overload are needed for individuals at the risk of IONPs in NAFLD.
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