4.7 Article

Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells

期刊

NANOMEDICINE
卷 16, 期 8, 页码 657-671

出版社

FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0427

关键词

anticancer activity; intracellular ROS; sono-synthesized ZnO NPs; tumor-selective cytotoxicity; ultrasonic bath

资金

  1. Ferdowsi University of Mashhad (Research and Technology) [3/44850]

向作者/读者索取更多资源

The study showed that the sono-synthesized ZnO nanoparticles exhibited higher cytotoxicity and tumor selectivity compared to conventionally synthesized ones. These nanoparticles acted as antioxidants and reduced intracellular reactive oxygen species levels, with the sono-synthesized sample showing more significant reduction.
Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 +/- 0.41 mu g/ml for sonochemical ZnO; 26.96 +/- 0.33 mu g/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据