期刊
NANO LETTERS
卷 21, 期 10, 页码 4270-4279出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c00408
关键词
bacteria; electron transport; AuNPs; photoelectricity; tumor therapy
类别
资金
- National Key Research and Development Program of China [2019YFA0905603]
- National Natural Science Foundation of China [51833007, 51690152]
The study introduced an optically controlled material-assisted microbial system that enhances the synthesis of antitumor drugs at tumor sites by biosynthesizing gold nanoparticles on bacterial surface. This system has the potential to provide a promising antitumor therapy strategy with improved drug synthesis efficiency in situ.
Engineered bacteria are promising bioagents to synthesize antitumor drugs at tumor sites with the advantages of avoiding drug leakage and degradation during delivery. Here, we report an optically controlled material-assisted microbial system by biosynthesizing gold nanoparticles (AuNPs) on the surface of Shewanella algae K3259 (S. algae) to obtain Bac@Au. Leveraging the dual directional electron transport mechanism of S. algae, the hybrid biosystem enhances in situ synthesis of antineoplastic tetrodotoxin (TTX) for a promising antitumor effect. Because of tumor hypoxia-targeting feature of facultative anaerobic S. algae, Bac@Au selectively target and colonize at tumor. Upon light irradiation, photoelectrons produced by AuNPs deposited on bacterial surface are transferred into bacterial cytoplasm and participate in accelerated cell metabolism to increase the production of TTX for antitumor therapy. The optically controlled material-assisted microbial system enhances the efficiency of bacterial drug synthesis in situ and provides an antitumor strategy that could broaden conventional therapy boundaries.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据