期刊
NANO LETTERS
卷 21, 期 8, 页码 3649-3656出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c00770
关键词
Magnetic nanoparticles; Magnetothermal heating; Thermal polymerization; Surface modification; Nanoparticles; Polymers
类别
资金
- Institute for Basic Science [IBS-R026-D1, IBS-R026-Y1]
A single nanoparticle coating method is reported to form 1 nm polymeric shells with various chemical functional groups and surface charges. Nanosecond thermal energy pulses triggered polymerization in the region only a few nanometers from the surface of magnetic nanoparticles under exposure to alternating magnetic field. Modular coatings with different functional groups and surface charges can be achieved by selecting appropriate monomers.
Nanoparticles with multifunctionality and high colloidal stability are essential for biomedical applications. However, their use is often hindered by the formation of thick coating shells and/or nanoparticle agglomeration. Herein, we report a single nanoparticle coating strategy to form 1 nm polymeric shells with a variety of chemical functional groups and surface charges. Under exposure to alternating magnetic field, nanosecond thermal energy pulses trigger a polymerization in the region only a few nanometers from the magnetic nanoparticle (MNP) surface. Modular coatings containing functional groups, according to the respective choice of monomers, are possible. In addition, the surface charge can be tuned from negative through neutral to positive. We adopted a coating method for use in biomedical targeting studies where obtaining compact nanoparticles with the desired surface charge is critical. A single MNP with a zwitterionic charge can provide excellent colloidal stability and cell-specific targeting.
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