期刊
NANO LETTERS
卷 21, 期 7, 页码 3066-3074出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c00204
关键词
surface-enhanced Raman spectroscopy; intraoperative guidance; residual microtumors; thermosurgery; photoacoustic imaging
类别
资金
- National Natural Science Foundation of China [51871246]
- Hunan Provincial Science & Technology Program [2017XK2027]
The study introduced a three-in-one theranostic nanoprobe for image-guided surgical resection of tumors and intraoperative surface-enhanced Raman spectroscopy (SERS) guided thermosurgical elimination of residual microtumors. In vivo experiments demonstrated complete eradication of microtumors without local recurrence and 100% tumor-free survivability, offering a robust platform for real-time intraoperative eradication of residual microtumors with significant improvement of surgical outcomes.
Residual microtumors following surgical resection are the major cause for lethal cancer recurrence. However, it remains challenging to completely eliminate these residual microtumors. Here, we report an integrated strategy for image-guided surgical resection of tumors and intraoperative surface-enhanced Raman spectroscopy (SERS) guided thermosurgical elimination of residual microtumors using a three-in-one theranostic nanoprobe, termed the Au nanostar-based photoacoustic (PA), SERS, and thermosurgical (starPART) probe. This starPART probe, comprising an Au nanostar core, a Raman molecule layer, and a silica outer layer, draws upon the significant advantages of PA imaging, SERS detection, and photothermal tumor ablation. These prominent features enable preoperative PA imaging for surgical resection of tumors and intraoperative SERS-guided thermosurgery for complete elimination of residual microtumors. In vivo experiments confirm complete eradication of microtumors without local recurrence and with a 100% tumor-free survivability. This work therefore offers a robust platform for real-time intraoperative eradication of residual microtumors with significant improvement of surgical outcomes.
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