期刊
MULTIPLE SCLEROSIS JOURNAL
卷 28, 期 1, 页码 71-81出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/13524585211010082
关键词
Chronic active lesions; iron rims; biomarkers; clinically isolated syndrome
The presence of iron rims in patients with a first demyelinating event is associated with higher T2 lesion volume, a higher number of gadolinium-enhancing lesions, and increased levels of CSF CHI3L1 and serum NfL.
Background: Chronic active lesions with iron rims have prognostic implications in patients with multiple sclerosis. Objective: To assess the relationship between iron rims and levels of chitinase 3-like 1 (CHI3L1), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with a first demyelinating event. Methods: Iron rims were identified using 3T susceptibility-weighted imaging. Serum NfL and GFAP levels were measured by single-molecule array assays. CSF (cerebrospinal fluid) CHI3L1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Sixty-one patients were included in the study. The presence of iron rims was associated with higher T2 lesion volume and higher number of gadolinium-enhancing lesions. In univariable analysis, having > 2 iron rims (vs 0) was associated with increased CSF CHI3L1 levels (beta = 1.41; 95% confidence interval (CI) = 1.10-1.79; p < 0.01) and serum NfL levels (beta = 2.30; 95% CI = 1.47-3.60; p < 0.01). In multivariable analysis, however, only CSF CHI3L1 levels remained significantly associated with the presence of iron rim lesions (beta = 1.45; 95% CI = 1.11-1.90; p < 0.01). The presence of > 2 iron rims was not associated with increased serum GFAP levels in univariable or multivariable analyses. Conclusion: These findings support an important contribution of activated microglia/macrophages to the pathophysiology of chronic active lesions with iron rims in patients with a first demyelinating event.
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