期刊
MOLECULES
卷 26, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules26092812
关键词
chalcone; trifluoromethyl group; prostate cancer; antitumor activity; target proteins
资金
- JSPS KAKENHI [25293024, 17H04325]
- IBM junior faculty grant
- Grants-in-Aid for Scientific Research [25293024, 17H04325] Funding Source: KAKEN
The study found that compound 5 exhibited potent antitumor activity by inducing cell death through cell cycle disruption, while also interacting with multiple cancer cell growth-related proteins.
alpha-Trifluoromethyl chalcones were prepared and evaluated for their antiproliferative activities against androgen-independent prostate cancer cell lines as well as five additional types of human tumor cell lines. The most potent chalcone 5 showed superior antitumor activity in vivo with both oral and intraperitoneal administration at 3 mg/kg. Cell-based mechanism of action studies demonstrated that 5 induced cell accumulation at sub-G1 and G2/M phases without interfering with microtubule polymerization. Furthermore, several cancer cell growth-related proteins were identified by using chalcone 5 as a bait for the affinity purification of binding proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据