期刊
MOLECULES
卷 26, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules26092637
关键词
furan; oxidation; cyclization; 2-ene-1; 4; 7-trione; Paal-Knorr reaction
资金
- Russian Science Foundation [19-73-00093]
- Russian Science Foundation [19-73-00093] Funding Source: Russian Science Foundation
A new approach to 3-(furan-2-yl)-1,3-di(het)arylprop-2-en-1-ones has been developed through the oxidative dearomatization and cyclization of di(het)aryl-substituted 2-ene-1,4,7-triones, showing high synthetic efficiency.
The approach to 3-(furan-2-yl)-1,3-di(het)arylprop-2-en-1-ones based on the oxidative dearomatization of 3-(furan-2-yl)-1,3-di(het)arylpropan-1-ones followed by an unusual cyclization of the formed di(het)aryl-substituted 2-ene-1,4,7-triones has been developed. The cyclization step is related to the Paal-Knorr synthesis, but the furan ring formation is accompanied in this case by a formal shift of the double bond through the formation of a fully conjugated 4,7-hydroxy-2,4,6-trien-1-one system or its surrogate.
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